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KMID : 1004620050110020205
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Clinical Nursing Research
2005 Volume.11 No. 2 p.205 ~ p.0
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Comparison of Heparin Flushing and Normal Saline Flushing for Patency of Central Venous Catheters in Hemato-Oncologic Patients
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Moon Cho-Hee
Yeon Bo-Ra
Kim Hyun-Jin
Eun Bang-Hee
Bae Young-Lee
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Abstract
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Purpose: The purpose of this study was to compare the efficacy of heparin flushing and normal saline flushing in maintaining patency of central venous catheters(CVCs), and to investigate relative risk factors of CVCs’ occlusion.
Method: A total of 159 patients who had been inserted with CVCs were included in the department of hemato-oncology of S hospital. The heparin group consisted of 74 patients with 10u/ml diluted heparin flushing from 23 November 2004 to 15 January 2005, and the normal saline group consisted of 85 patients with 0.9% normal saline flushing from 19 January to 31 March of 2005.
Result: The heparin group was significantly different from the normal saline group in CVCs’ occlusion. The normal saline group offered a much longer survival duration of CVCs’ patency than the heparin group. Potential bleeding signs (PT, aPTT) had no significant differences. In multivariate analysis, 0.9% normal saline (hazard ratio 0.50), chemo port (hazard ratio 3.38), and no administration of TPN (hazard ratio 0.25) were the significant factors for occlusion of CVCs.
Conclusion: For maintaining the patency of CVCs, 0.9% normal saline flushing are expected to be effective in reducing drug incompatibilities, lessening the bleeding tendency and improving cost effectiveness.
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KEYWORD
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Central Venous Catheter, Heparin Flushing, Normal Saline Flushing
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